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The CD37 antigen is a 40-52 kDa single chain transmembrane protein with 4 transmembrane domains (Tetraspan/TM4SF). This molecule has both its NH2- and COOH-termini inside the cells, and is heavily glycosylated on one extracellular loop. The main feature of this antigen is its high content of hydrophobic residues (45%). The CD37 antigen is strongly expressed on the surface of human peripheral blood B lymphocytes and on B lymphocytes from germinal centers. In the ontogeny of B cells, this antigen appears late, after the pre-B stage, and is not expressed on plasma cells. The CD37 antigen has a low expression on T lymphocytes, granulocytes, and monocytes. A weak reactivity is observed with other cellular types such as Langerhans cells, macrophages, normal medullar granulous cells and peripheral blood polymorphonuclear cells. CD37 is involved in signal transduction.
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