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Other areas of Immunotherapy


CAR-T Cells CAR-T cells for research and therapeutic purposes requires a CAR-T cell production workflow
Explore CRISPR CRISPR-guided gene editing has tremendous potential for immunotherapy research
Viral Vectors Viral systems play an important role in the production of recombinant proteins

Resources and Immunotherapy Documentation

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Title	Description
What is a biomarker? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explanation around what biomarkers are and where and how they are used
Efficient Kit-Free Nucleic Acid Isolation uses a Combination of Precipitation and Centrifugation Separation Methods {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Author: Julia P Luciano-Chadee, Beckman Coulter, Inc., Indianapolis, IN 46268 \| Published 2017
Centrifugation is a Complete Workflow Solution for Protein Purification and Protein Aggregation Quantification {749D68FB-4893-4B2D-BD6C-C662F0520F64}	Author: Julia P Luciano-Chadee \| Beckman Coulter Life Sciences, Inc., Indianapolis, IN 46268 \| Published 2017
What are peptide-based vaccines? {C761825C-5739-42D5-90E3-D058FB587ADC}	Definition of peptide-based vaccines and discussion around the principle and benefits that align
What is half-life and why is it important for immunotherapy drugs? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss what half-life is and why is it important for immunotherapy drugs through several forms of immunotherapy
What is immune evasion? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define immune evasion and how checkpoints play an important role
What happens when the immune system does not function properly? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss what an immune system is designed to do and what happens when the immune system does not function properly
What diseases can be treated using newly approved immunotherapies? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore what diseases can be treated using newly approved immunotherapies (2018)
What is the difference between active immunotherapy and passive immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explore the difference between active immunotherapy and passive immunotherapy
How do cancer cells bypass TCR-mediated T cell recognition? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine how cancer cells bypass TCR-mediated T cell recognition and important tactics involved
What is the T cell receptor and why is it critical? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what the T cell receptor is, why it's critical, and what is all involved
What approaches are being considered to improve therapeutic safety? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine what approaches are being considered to improve therapeutic safety and potential methods associated
How are T cells isolated and expanded? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss how T cells are isolated and expanded in CAR-T cell production
What is the future of CRISPR? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the future of CRISPR and how it fits into specific applications and outside of relevant industries
How does CRISPR/Cas work? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the CRISPR/Cas system (clustered regularly interspaced short palindromic repeats) and the details that surround the subject
Is there an immunotherapy available for every type of cancer? {C761825C-5739-42D5-90E3-D058FB587ADC}	The effectiveness of immunotherapy for different types of cancer
How can CRISPR gene therapy impact medicine? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the impact CRISPR gene therapy has on medicine and examines CRISPR applications
What is the endogenous purpose of CRISPR? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the endogenous purpose of CRISPR (clustered regularly interspaced short palindromic repeats)
Are all immunotherapies cell-based? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around cell-based immunotherapies and related areas of interest
What are the key considerations to optimizing viral vector production? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the key considerations to optimizing viral vector production and the workflows that are involved
Why should I use a vector for gene transfer? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around gene transfer by means of using a vector and related information on the process
What are the challenges of using viral vectors for therapeutic applications? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what challenges exist for using viral vectors for therapeutic applications
What safety considerations need to be taken when producing viral vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what safety considerations need to be taken when producing viral vectors
What are adenoviruses (Ads) and why are they used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define adenoviruses (Ads) and explain why they are used as vectors, and the process that takes place
What are herpes simplex viruses (HSVs) and why are they used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define herpes simplex viruses (HSVs) and explain why they are used as vectors, and the process that takes place
Which Biomaterials can be used to enhance immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore which biomaterials can be used to enhance immunotherapy and the benefits that follow the processes
What are the differences between oral- sublingual-, and dermal immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine the differences between the different types of immunotherapy, including oral, sublingual, and dermal
How can immunosuppressants be used for immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how immunosuppressants can be used for immunotherapy and how other methods compare or contrast
How can cytokines help boost the immune system? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how cytokines can help boost the immune system and provide specific examples that align
What are the differences between TCRs, TILs, and CAR-Ts in immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine the differences between TCRs (T-cell receptors), TILs (tumor-infiltrating lymphocytes), and CAR-Ts (chimeric antigen receptor-T cells) in immunotherapy
How can I assess the mechanisms of antigen loss to uncover novel immunotherapeutics? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how the mechanisms of antigen loss to uncover novel immunotherapeutics can be assessed
What are some challenges in developing vaccines for immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around some of the challenges in developing vaccines for immunotherapy as well as development barriers
How can tumors be targeted using immunocytokines? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how tumors can be targeted using immunocytokines and the development and benefits that align
What are some strategies for enhancing local delivery of immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around some strategies for enhancing local delivery of immunotherapy and areas of focus where it relates
How can you use single cell analysis for immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss how single cell analysis for immunotherapy can be used and what it allows researchers to identify
What is the difference between CRISPR (clustered regularly interspaced short palindromic repeats) and TALENs (transcription-activator-like effector nucleases)? {C761825C-5739-42D5-90E3-D058FB587ADC}	CRISPR (clustered regularly interspaced short palindromic repeats) and TALENs (transcription-activator-like effector nucleases) differences and details
Are there different CRISPR-associated system (Cas) proteins? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how different protein families associate with CRISPR (clustered regularly interspaced short palindromic repeats)
What ethical dilemmas need to be considered when working with CRISPR technology? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss what ethical dilemmas need to be considered when working with CRISPR technology
What are some of the ways CRISPR can enhance improved therapeutic agents? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around some of the ways CRISPR can enhance improved therapeutic agents
What are the main components of a CRISPR/Cas system? {C761825C-5739-42D5-90E3-D058FB587ADC}	Main components of a CRISPR/Cas system and the details around the subject
Where can I find out about immunotherapy clinical trials? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around immunotherapy clinical trials and important links for the topic
Do tumors develop resistance to immunotherapies? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explore tumor resistance in relationship with immunotherapy
What is CRISPR? {C761825C-5739-42D5-90E3-D058FB587ADC}	Definition and details for CRISPR (clustered regularly interspaced short palindromic repeats)
What is combination therapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around combination therapy, the history behind it, and where it is going
What are neoantigens? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around neoantigens and the relationship to immunotherapies
How can nanoparticles be used for immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine how nanoparticles can be used for immunotherapy as well as in other research areas
What is mutational load and how does it apply to immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define mutational load and discusses how it applies to immunotherapy as well as how it aligns with relevant methods
What is cellular immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define cellular immunotherapy and provide a specific example for clarity
What is targeted immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define targeted immunotherapy and discusses some of the methods and approaches that align
What are the differences between RNA and DNA viruses used in immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the differences between RNA and DNA viruses in immunotherapy as well as related information and processes
Why would I deliver foreign nucleic acids into a cell? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine the introduction of foreign genes into a cell and genomic changes made by gene transfers
What is the history of chimeric antigen receptors (CARs)? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the history of CARs (chimeric antigen receptors) through each specific generation
How do you produce a viral vector? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the production of viral vectors and what processes and workflows that apply
How does a viral vector work? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine the capabilities of viral vectors and the process of how they work and what they may affect
What is the difference between non-homologous end joining (NHEJ) and homology-directed repair (HDR)? {C761825C-5739-42D5-90E3-D058FB587ADC}	Non-homologous end joining (NHEJ) and homology-directed repair (HDR) related to CRISPR
What is the difference between the innate and adaptive immune systems? {C761825C-5739-42D5-90E3-D058FB587ADC}	The difference between the innate and adaptive immune systems
What is antigen specific immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define antigen specific immunotherapy and examine recent immunotherapies for examples
What is immuno-oncology? {C761825C-5739-42D5-90E3-D058FB587ADC}	A detailed explanation of immuno-oncology and its alignment to other therapies
Where do the cells for cell-based immunotherapies come from? {C761825C-5739-42D5-90E3-D058FB587ADC}	Details around the cells that are used for cell-based immunotherapies
Will immunotherapy be successful for treating diseases like HIV/AIDS? {C761825C-5739-42D5-90E3-D058FB587ADC}	Will immunotherapy be successful for treating diseases like HIV/AIDS
How do oncolytic viruses target cancer cells in immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine how oncolytic viruses target cancer cells in immunotherapy and how genetically modified viruses apply
How are CAR-T cells produced? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how CAR-T cells are produced and the workflows that follow
How do chimeric antigen receptors (CARs) work? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine how CARs (chimeric antigen receptors) work and what comes from their interaction
How has CRISPR impacted research when it comes to studying gene alterations and function? {C761825C-5739-42D5-90E3-D058FB587ADC}	CRISPR (clustered regularly interspaced short palindromic repeats) impact on research relative to gene alterations and function
How is the CAR receptor introduced to the T cell? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how the CAR receptor is introduced to the T cell and the delivery methods that are involved
What components and domains make up a chimeric antigen receptor (CAR)? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore what components and domains make up a chimeric antigen receptor (CAR)
What is the difference between CRISPR and RNAi (RNA interference)? {C761825C-5739-42D5-90E3-D058FB587ADC}	CRISPR and RNAi (RNA interference) differences and details
What is the future of CAR-T research and therapeutics? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the future of CAR-T research and therapeutics, and the possibilities for CAR development and progress
What is a chimeric antigen receptor (CAR)? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what a chimeric antigen receptor (CAR) is and how it relates to T cells
What is the difference between CRISPR and ZFNs (zinc finger nucleases)? {C761825C-5739-42D5-90E3-D058FB587ADC}	CRISPR (clustered regularly interspaced short palindromic repeats) and ZFNs (zinc finger nucleases) differences and details
How can CRISPR-mediated genetic engineering impact industrial productivity and nature? {C761825C-5739-42D5-90E3-D058FB587ADC}	CRISPR-mediated genetic engineering and its impact industrial productivity and nature
What other types of immune cells are there and how do they contribute to immune-mediated killing mechanisms? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss what other types of immune cells there are and how they contribute to immune-mediated killing mechanisms
What are macrophages? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define macrophages and discuss their role in immune response
Which diseases have immunotherapies been effective in treating? {C761825C-5739-42D5-90E3-D058FB587ADC}	Which diseases immunotherapies have been effective in treating and the current research technology
What is immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explore the broad subject of immunotherapy and the related areas that surround the trending topic
What are B cells? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define B cells and discuss their greater role in immune response
Are CAR-T cells used for therapeutic purposes? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine if CAR-T cells are being used for therapeutic purposes and the potential behind them
How do I select, expand, and store CAR-T cells? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how to select, expand, and store CAR-T cells and specific factors involved in the process
Are there side effects with CAR-T cells? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore if there are side effects with CAR-T cells and the extent to which they can become
What antigens can a CAR-T cell target? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what antigens a CAR-T cell can target and for what purposes
Are there different types of immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the different types of immunotherapies and the dependencies that align
Are there any drawbacks or side-effects to the use of immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around the use of immunotherapy and its potential drawbacks or side-effects
What are PAM sequences? {C761825C-5739-42D5-90E3-D058FB587ADC}	PAM sequences and related information around the subject
What is a guide molecule? {C761825C-5739-42D5-90E3-D058FB587ADC}	Questions around a guide molecule relative to CRISPR-associated Cas9 (clustered regularly interspaced short palindromic repeats)
How are biomarkers used for diagnostic screening in immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how biomarkers are used for diagnostic screening in immunotherapy
How can adjuvants be improved for immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how adjuvants can be improved for immunotherapy and related FDA regulations that apply
How can immunotherapy help with inflammatory bowel disease (IBD)? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how immunotherapy can help with inflammatory bowel disease (IBD)
How can immune checkpoint inhibitors be used to boost immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how immune checkpoint inhibitors can be used to boost immunotherapy and we provide specific examples
How do viral vectors compare to other approaches in terms of efficacy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how viral vectors compare to other approaches in terms of efficacy
How does the immune system eliminate harmful cells? {C761825C-5739-42D5-90E3-D058FB587ADC}	We examine how the immune system eliminates harmful cells and the process that is involved
What's the difference between chemotherapy, radiation, and immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explore the unique details behind chemotherapy, radiation, and immunotherapy
How does the immune system recognize harmful entities? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how the immune system recognizes harmful entities and the responses that follow
What is the difference between the different T cell types? {C761825C-5739-42D5-90E3-D058FB587ADC}	We discuss the difference between the different T cell types and what their functions are
What are T cells? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define T cells and discuss where they are most well-known and the different subsets that exist
What does the immune system do? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around what the immune system does and how internal and external threats may affect the body's defense system
What is adoptive cell transfer? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define adoptive cell transfer and discuss commonly used forms and what's related
How can small molecule drugs help boost the immune system? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore how small molecule drugs can help boost the immune system
Can immunotherapy be used to slow down aging? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the potential benefits immunotherapy can have on slowing down the process of aging
What is Bacillus Calmette-Guerin? {C761825C-5739-42D5-90E3-D058FB587ADC}	Definition for Bacillus Calmette-Guerin (BCG) as it relates to immunotherapy and bladder cancer
How do local tissue environmental conditions affect immune function? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around how local tissue environmental conditions affect immune function
What are lentiviruses and why are they used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	The definition of lentiviruses and explanation of why they are used as vectors, and the process that takes place
What are retroviruses and why are they used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	The definition of retroviruses and explanation of why they are used as vectors, and the process that takes place
What does targeting blood vessels have to do with immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	Explanation around what targeting blood vessels have to do with immunotherapy
What are adeno-associated viruses (AAVs) and why are they used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	We define adeno-associated viruses (AAVs) and explain why they are used as vectors, and the process that takes place
What types of viruses are commonly used as vectors? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore what types of viruses are commonly used as vectors as well as related research, potential, and considerations
What are popular immunotherapy approaches? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the most popular immunotherapy approaches and if they are cell- or molecular-based mechanisms
Can immune function be therapeutically restored or enhanced? {C761825C-5739-42D5-90E3-D058FB587ADC}	Discussion around if immune function can be therapeutically restored or enhanced and how it reacts to diseases
What do I need to consider when selecting a viral vector candidate? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the questions that need to be answered when selecting a viral vector candidate
What is the potential of immunotherapy? {C761825C-5739-42D5-90E3-D058FB587ADC}	We explore the potential of immunotherapy and immunotherapy research as related to many areas, including cancer, disease, and more
Recent Advances in Immunotherapy: Directing Cells to Address Disease	Watch this webinar on the recent advances in immunotherapy with a focus on directing cells to address disease, presented by Leena Gandhi MD PhD
Analytical Methods to Measure Empty and Full AAV Particles	Review around biophysical characterizing techniques and a focus on the use of analytical ultracentrifugation (AUC) for measuring empty and full AAV particles
Is Immunotherapy Living up to its Promise?	Watch this webinar on the advancements and performance of immunotherapy, presented by Jill O'Donnell-Tormey and Alex Y. Huang
Advanced Flow Cytometric Analysis of Human T-Cell Memory Subsets	Multi-color flow cytometry is a powerful tool to analyze the highly heterogeneous human T cell compartment
Centrifugal Elutriation - Utility in the Flow Cytometry Laboratory	Dr. Peter Lopez will help you understand the utility of centrifugal elutriation in modern flow cytometry labs
The Use of the Analytical Ultracentrifuge to Characterize Very Large Complex Biopharmaceuticals	This webinar covers the key attributes of AUC as a highly effective technique for characterizing viral vectors for viral gene therapy delivery systems
Development and Production of Viral Vectors: Advances in Processes and Translation for Human Gene Therapy	Understand the role viral vectors play in modern gene research and how ultracentrifugation is used to produce these key delivery systems
Evolution in the Manufacturing of Cellular Therapies {8ED0B7A0-4EDF-41AC-9D0B-3950E79F42E4}	Lessons learned and current solutions Immunotherapy is a powerful treatment that harnesses the body’s immune system in the fight against cancer. With optimized cell therapy, the result is an expanded population of T cells primed to recognize and eradicate malignant tumor cells that would otherwise escape immune detection. The webinar will discuss how cellular therapies have evolved, lessons learned through the evolution and current solutions available today. Learning Objectives: Commercialization of manufacturing- preparing a CAR Garage, lessons learned and how does it impact the patient. Automated functional testing- fully integrated unit operations taking the art out of science!
Applications of Counterflow Centrifugal Elutriation CCE	Applications of Counterflow Centrifugal Elutriation CCE and the history and principle behind it
How Stem Cells Speak with Immune Cells	Watch this webinar from Stefan Pluchino on how stem cells signal to the host immune system
CAR-T Cell Therapy: Introduction and Overview {FBC52A26-B43E-46C3-A091-65AAEFBE5885}	Featured video on the introduction of CAR-T cell therapy as related to immunotherapy
CRISPR for Immunotherapy: Introduction and Overview {FBC52A26-B43E-46C3-A091-65AAEFBE5885}	Featured video on the introduction to CRISPR for immunotherapy
Immunotherapy Introduction and Overview {FBC52A26-B43E-46C3-A091-65AAEFBE5885}	Discussion around the basics of immunotherapy and related agents and techniques that are commonly used
Viral Vectors Introduction and Overview {FBC52A26-B43E-46C3-A091-65AAEFBE5885}	Watch this viral vectors overview and introduction video
Cell Therapy: From Research to Commercialization {3AB28F00-B7FC-47D9-80F2-C0E49A388F7B}	eBook discusses an overview of the steps to commercialization for a cellular therapy, including scaling up production, the advantages of automation, common obstacles, and compliance and regulatory issues
Virus Production Workflow – Centrifugation Highlights {A0D0EF0B-43F2-431C-BEB0-69F98765BDC4}	Preparation of production cell line
Going Viral {A0D0EF0B-43F2-431C-BEB0-69F98765BDC4}	Choosing a viral delivery system is a bit like choosing a partner
Virus Purification Workflow – Centrifugation Highlights {A0D0EF0B-43F2-431C-BEB0-69F98765BDC4}	Centrifuge to harvest cells containing virus
Protein Production Workflow – Centrifugation Highlights {A0D0EF0B-43F2-431C-BEB0-69F98765BDC4}	Preparation of production cell line - thaw, grow, expand
Protein Purification Workflow – Centrifugation Highlights {A0D0EF0B-43F2-431C-BEB0-69F98765BDC4}	Centrifuge to harvest cells containing protein
Manufacturing Processes for Engineered T-Cell Therapy – CAR-T	Brochure presenting the CAR-T cell therapy workflow and associated product portfolio

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