Perforin is a 70 kD N-glycosylated modified cytolytic protein. Following synthesis and posttranslational modifications, perforin monomers are packaged into lysosome-like cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Both types of cells kill their cellular targets by mechanisms that require direct contact between the effector and target cells. Cytoplasmic granule toxins, predominantly perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities are secreted by exocytosis and together induce apoptosis of the target cell. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.
|Clone: dG9||Isotype: IgG2b Mouse|
Choose a Perforin Model
Product Line Specifications
|Flow Product Line||IOTest|
|Item Specifications Referenced||B46030|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.