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CD11a (αL integrin, LFA-1 α chain) is a member of the integrin family. Like some other leucocyte integrins (CD11b, CD11c, CD11d), CD11a is non-covalently associated with the β2 integrin subunit CD18. CD11a is a transmembrane glycoprotein of 170 kDa, mainly expressed by leucocytes including monocytes, macrophages, neutrophils, eosinophils, basophils, B and T lymphocytes. Activated platelets also express CD11a and CD18. LFA-1 (CD11a/CD18) promotes homotypic adhesion between lymphoid cells and heterotypic adhesion of leucocytes to the vascular endothelium. LFA-1’s known ligands are Intercellular Adhesion Molecules (ICAM): ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50).
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS
The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.
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