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The CD28 antigen (Tp44) is a homodimer of disulfide-linked chains, with a molecular weight of 44 kDa each. CD28 antigen is expressed by a majority of CD3+ T lymphocytes. CD4+ T lymphocytes express the CD28 antigen more frequently than do CD8+ T lymphocytes. CD28 antigen is also present on plasma cells and thymocytes. This antigen is involved in the adhesion of T lymphocytes with B lymphocytes, through the B7/BB-1 (CD80) or B70/B7-2 (CD86) glycoproteins and provides a major co-stimulatory signal for T cell activation.
*Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
CD28, CD80/CD86 Ligand, Tp44
APC-Alexa Fluor* 700
Flow Product Line
The CD28.2 monoclonal antibody costimulates T cell proliferation and cytokine production in the presence of T cell activators (αCD3, PMA, SEB). It inhibits proliferation of CD4+ T lymphocytes. It cross-reacts with Rhesus monkey peripheral blood lymphocytes.
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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.
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