Some features of beckman.com will be unavailable from 8:00 p.m. PDT Saturday, December 7 until 12:00 a.m. PDT, Sunday, December 8 for planned maintenance. During this time, you will not be able to log in to use account features such as online shopping, shopping lists and order tracking.
Please ensure your orders are processed prior to this maintenance period or contact Client Services for additional assistance.
The natural killer (NK), T lymphocyte, B lymphocyte antigen (NTB-A) is a 60-kDa transmembrane glycoprotein of the CD2 family expressed on all human resting and activated NK, T and B cells. This antigen is not expressed on monocytes, neutrophils, and basophils but is expressed on eosinophils. The NTB-A antigen, a 331 amino acid protein, is a member of the immunoglobulin (Ig) superfamily. It is characterized, in its 225 amino acid extracellular domain, by one distal V-type domain without disulfide bond and two proximal C2-type domains, and in its 83 amino acid cytoplasmic domain by three tyrosine residues. One tyrosine residue is part of an ITIM motif and two are parts of an ITSM motif (TxYxxV/I). NTB-A is its own ligand through an homophilic binding. NTB-A associates with two adaptor proteins, the SLAM–associated protein (SAP) also known as SH2D1A and the Ewing’s sarcoma activated transcript (EAT) 2. In NK cells, NTB-A acts as an activating coreceptor.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
There are currently no Technical Documents associated with this page or product. Please try our Technical Documents search
Related Products or Parts
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.