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Also called TCRBV11S1
Vβ11 is the human variable β11 chain of the T cell receptor. Two Vβ11 sequences are described, PL3.12 and PH15. These sequences differ only in their leader sequence and therefore lead to the same mature protein. An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonal expanded CD4– CD8– T cells, reactive to bacterial antigens. This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. Vβ11 is expressed by 0.4% to 0.9% of peripheral CD3+ cells in normal blood. This sequence is also referred to as TRBV25-1 (based on the IMGT gene nomenclature).
TCR VBeta 11, TCRBV11S1
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The C21 recognizes the gene product of PL3.12 and PH15 sequences. The specificity of this antibody has been confirmed at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995.
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